Letrozole (Letrozol)


  • Brand: Balkan Pharmaceuticals
  • Country of manufacture: Moldova
  • Release form: Tablets
Categories: ,


Information for all who need to buy Letrozole (Letrozol) Contents Expand

  • Letrozole in bodybuilding
  • Scope of Letrozole in medicine
  • Dosage
  • Side effects
  • Interactions with other drugs
  • Chemical composition

You can buy Letrozole, which belongs to the substances of the aromatase group, thanks to the conversion of androgens into estrogens, in our online store of anabolic steroids Hulk Shop, at very affordable prices. Among other things, the level of estrogen will be reduced when taking Letrozole (according to studies up to 75%). This is especially interesting for bodybuilders who use AAS (anabolic/androgenic steroids) to counteract the side effects. However, Letrozole in bodybuilding courses is used to support fat loss and to create a lean and tight looking muscle during competition preparation.

Aromatase inhibitors, such as Letrozole, block the aromatase enzyme. This procedure reduces the conversion of testosterone to estrogen. Letrozole is an aromatase inhibitor that competes with testosterone. They are also called aromatase inhibitors type II.

Letrozole in bodybuilding

An estrogen blocker such as Tamoxifen or Clomiphene (Clomid) can reduce the side effects of anabolic steroids (AAS) associated with estrogen, sufficient in most cases. These aromatase inhibitors are, on the one hand, cheaper than Letrozol, and on the other hand, they have a positive effect on cholesterol levels, since they have an effect similar to cholesterol in the liver.Letrozol is used today mainly for bodybuilding competition preparation because, as already mentioned, it supports fat loss as well as muscle wasting and lowers estrogen levels.

There is a constant rumor in bodybuilding that gynecomastia can be completely eliminated by the simple use of Letrozole. However, this should be considered with caution. In the case of gyna, you should always consult your doctor.

Scope of Letrozole in medicine

Most forms of breast cancer can be stimulated by the female sex hormone estrogen. Letrozole is used against hormone-dependent breast cancer in postmenopausal women to discount the rate of tumor growth. It is used as an anti-cancer drug in patients undergoing artificial menopause by removing the ovaries.

Estrogen promotes cancer growth and seeding of cancer cells in the rest of the body (metastases) in estrogen-sensitive tumors. With the withdrawal of estrogen, this particular tumor, such as the growth of breast cancer, stops. Some medicines take advantage of this fact. These also include active substances from the group of aromatase inhibitors, such as Letrozole. Like all aromatase enzymes, the active ingredient of the aromatase blocking enzyme is important for the formation of estrogen.

Before menopause, the ovaries are the headquarters of estrogen by aromatase. The ovaries are aromatase inhibitors but are ineffective and cannot suppress estrogen production. In addition, a small amount of estrogen in the liver, adrenal glands is formed by aromatase in adipose tissue cells and – fatally – also in breast cancer cells. In these tissues, estrogen production continues after menopause.However, it can now be blocked while taking Letrozole. Therefore, the production of estrogen that remains after menopause also decreases.


In the medical field, the dosage of the aromatase inhibitor Letrozole is 2.5 mg per day. It has been shown in various clinical studies, but this is already with doses of 0.1 to 0.5 mg of 75% suppression of estrogen production.

Letrozole is often used by bodybuilders during doping to neutralize the side effects of estrogen. Dosages are generally much lower than in the medical field, so doses to reduce estrogen-related side effects are 0.25 to 1.25 mg letrozole to be taken every two days. Due to the active substance, letrozole has a half-life of more than two days (about 50 hours), usually every other day is sufficient.

Side effects

  • sweating
  • Joint pain
  • tides
  • Fatigue
  • Weakness
  • Loss of appetite
  • Appetite increase
  • Excess cholesterol in the blood
  • Depression
  • Headaches
  • Dizziness
  • Nausea and vomiting
  • Heartburn
  • constipation
  • Diarrhea
  • Hair loss
  • Rash
  • Muscle pain
  • Bone loss (osteoporosis)
  • Water retention in arms and legs.

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Interactions with other drugs

Among other things, the cytochrome P-450 2A6 enzyme is hampered by Letrozole. Substances that decompose and are toxic even with a slight overdose of this enzyme should not be taken.

Letrozole may not be used in women who are not yet menopausal or who have adequate hormone levels in their blood.

The active ingredient should only be used under medical supervision in patients with hepatic or renal impairment.

Chemical composition

  • Molecular formula: C 17 H 11 N 5
  • Molecular weight: 285.303 g/mol
  • Monoisotopic mass: 285.101440 da
  • Elimination half-life: 50 hours.
  • Letrozole is a white to yellowish crystalline powder, practically odorless.

    It is soluble in dichloromethane, sparingly soluble in ethanol, and insoluble in water.

    Letrozole is a very sensitive substance and should be kept constant at 25 degrees Celsius. Do not expose to temperatures over 30 degrees Celsius. Storage conditions must be dry.


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